🔗 Share this article Patients Stopping Anti-Obesity Injections Gain Back Pounds at a Quadrupled Rate Compared to People Using Diet and Exercise Weight management often requires long-term strategies. New research reveals that individuals who stop using new GLP-1 drugs like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who end traditional lifestyle programs. Findings released in a major medical journal points out that while obese people frequently drop a large proportion of their total mass while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month upon discontinuation. "Users purchasing such medications should be informed of the risk of quick weight regain when the treatment is stopped," warns researcher Dr. Susan Jebb. That rate of recovery implies a reversion to original weight in about 18 months. Comparing Treatments The research, which reviewed dozens of studies involving over 9,000 of participants, compared the outcomes of the injectable medications with other pills. The team note that people who lose weight through dieting generally experience a slower weight regain—perhaps 0.1 kg a month—once they finish. The Reason for the Fast Regain Nutrition scientists suggest the mechanism of the injections explains the heightened regain. These medications mimic a body's own chemical called GLP-1, which controls hunger. "Sustained high doses of the hormone levels several times higher than normal might result in the body to generate a reduced amount of its own natural GLP-1, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert. "Withdrawal of this medication results in hunger is unsuppressed, making overeating much more probable." A Chronic Disease? Health authorities advise the jabs for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications. A number of clinicians say that, considering the significant potential of relapse, the treatment might need to be life-long. This opinion is supported by drug manufacturers, who state that the results "highlight the chronic character of excess weight," comparing it to managing conditions like diabetes. User Accounts Users who have come off the jabs explain a intense return of cravings. "It felt as if a switch that goes on and you're instantly extremely hungry," said one woman. This challenge is exacerbated if users have not developed sustainable lifestyle or habit modifications during therapy. Significant Adoption Figures suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand remaining high. Use is higher among women than men. The middle-aged age group shows the greatest usage rates. Many obtain the drugs through private prescriptions rather than the NHS. In conclusion, researchers emphasize that while these medications are potent tools for shedding pounds, they are not a magic fix and lasting health benefits relies on combined lifestyle management.
Weight management often requires long-term strategies. New research reveals that individuals who stop using new GLP-1 drugs like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who end traditional lifestyle programs. Findings released in a major medical journal points out that while obese people frequently drop a large proportion of their total mass while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month upon discontinuation. "Users purchasing such medications should be informed of the risk of quick weight regain when the treatment is stopped," warns researcher Dr. Susan Jebb. That rate of recovery implies a reversion to original weight in about 18 months. Comparing Treatments The research, which reviewed dozens of studies involving over 9,000 of participants, compared the outcomes of the injectable medications with other pills. The team note that people who lose weight through dieting generally experience a slower weight regain—perhaps 0.1 kg a month—once they finish. The Reason for the Fast Regain Nutrition scientists suggest the mechanism of the injections explains the heightened regain. These medications mimic a body's own chemical called GLP-1, which controls hunger. "Sustained high doses of the hormone levels several times higher than normal might result in the body to generate a reduced amount of its own natural GLP-1, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert. "Withdrawal of this medication results in hunger is unsuppressed, making overeating much more probable." A Chronic Disease? Health authorities advise the jabs for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications. A number of clinicians say that, considering the significant potential of relapse, the treatment might need to be life-long. This opinion is supported by drug manufacturers, who state that the results "highlight the chronic character of excess weight," comparing it to managing conditions like diabetes. User Accounts Users who have come off the jabs explain a intense return of cravings. "It felt as if a switch that goes on and you're instantly extremely hungry," said one woman. This challenge is exacerbated if users have not developed sustainable lifestyle or habit modifications during therapy. Significant Adoption Figures suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand remaining high. Use is higher among women than men. The middle-aged age group shows the greatest usage rates. Many obtain the drugs through private prescriptions rather than the NHS. In conclusion, researchers emphasize that while these medications are potent tools for shedding pounds, they are not a magic fix and lasting health benefits relies on combined lifestyle management.